Scientific research links genes to depression in older men

Research at the Western Australia Centre for Health and Ageing has demonstrated an increased risk of depression in people who a genetic polymorphism of the C-Reactive Protein (CRP) gene. CRP is a protein “found in the blood in response to inflammation”. Already knowing depression is prevalent among older Australians, researchers used the electorol role to randomly select 12,000 men aged 65, or older, living in Perth. 3,700 men consented to blood tests for genetic analysis, which, along with other health and lifestyle factors, contributed to this finding.

Professor Osvaldo Almeida, Centre Research Director, stated “The results of our study suggest that these genetic variations lead to a relative deficiency in an individual’s ability to address the physiological changes that occur as a result of acute stressful events. The consequence of such a deficit is that the body takes much longer to be restored to full health, and depression may ensue because of the ongoing high circulating levels of chemicals known as cytokines.”.

The consequent challenge to such studies as this is to find the practical application for improved management and treatment strategies, but as Professor Almeida commented: “A lot of work has to go into that.”.

Article: http://www.sciencealert.com.au/news/20091905-19141-2.html

Original Source: http://www.news.uwa.edu.au/200905181199/media-statements/scientific-breakthrough-links-gene-controls-immune-response-depression

Original Study: Edition not yet published, Current Issue:(Volume 38 Issue 2 April 2009)